Treatment of blepharospasm with botulinum A toxin.

Kim,  Yoon Duck; Levine,  Mark R.

doi:1987.1.2.102

Korean J Ophthalmol > Volume 1(2); 1987 > Article

Comparative Study

Korean Journal of Ophthalmology 1987;1(2):102-108.
DOI: https://doi.org/10.3341/kjo.1987.1.2.102 Published online December 30, 1987.

Treatment of blepharospasm with botulinum A toxin.

Yoon Duck Kim, Mark R. Levine

¹Division of Ophthalmology, Eulji Hospital, Seoul, Korea.
²Division of Ophfhalmoiogy, The Mt. Sinai Medical Center, Cleveland, Ohio, U.S.A.

Abstract

Thirty-nine patients with blepharospasm were treated with botulinum A toxin. Twenty-six patients had essential blepharospasm, and thirteen had a hemifacial spasm. A total of 113 injections were given, and the average follow-up was 14.6 months. The mean preinjection spasm intensity was 2.9+ and the mean postinjection spasm intensity was 0.7+. The mean interval between injections was 4.4 months. The treatment was effective, although transient, in all patients with essential blepharospasm and hemifacial spasm. The toxin had a prolonged effect on the patients who had previously undergone muscle stripping procedure. The side effects were mild, transient, and local.

Key Words: essential blepharospasm;hemifacial spasm;botulinum A toxin