Intraocular infusate with hemocoagulase for the control of bleeding during vitreous surgery.

Lee,  Ho Sung; Kim,  Sang Ha; Kim,  In Taek

doi:1989.3.1.6

Korean J Ophthalmol > Volume 3(1); 1989 > Article

Original Article

Korean Journal of Ophthalmology 1989;3(1):6-10.
DOI: https://doi.org/10.3341/kjo.1989.3.1.6 Published online June 30, 1989.

Intraocular infusate with hemocoagulase for the control of bleeding during vitreous surgery.

Ho Sung Lee, Sang Ha Kim, In Taek Kim

Department of Ophthalmology, College of Medicine, Kyung-Pook National University, Taegu, Korea.

Abstract

The effects of hemocoagulase in injectable form (hemocoagulating enzymatic fraction of South American snake Bothrops jararaca venom provided by Ravizza) on the control of intraocular bleeding during vitreous surgery were evaluated in rabbit eyes. Intraocular infusion solution with hemocoagulase (1 NIH thrombin unit/100 ml of BSS plus) significantly reduced the bleeding time. Electroretinogram b-wave and electroretinogram c-wave showed no abnormality. Infusate with hemocoagulase (1 NIH thrombin unit/100 ml of BSS plus) is not toxic to retinal tissue and appeared to be a useful agent for the control of intraocular bleeding during vitreous surgery.

Key Words: hemocoagulase;bleeding time;vitrectomy;retinal toxicity