Korean J Ophthalmol > Volume 9(1); 1995 > Article
Korean Journal of Ophthalmology 1995;9(1):12-18.
DOI: https://doi.org/10.3341/kjo.1995.9.1.12    Published online June 30, 1995.
Safety of intravitreally injected ciprofloxacin in phakic rabbit eyes.
Sang Ha Kim, Jae Hong Kim, Kyung Shin Cho, Jung Sik Kwak
1Department of Ophthalmology, School of Medicine, Kyungpook National University, Taegu, Korea.
2Department of Ophthalmology, Maryknoll Hospital, Pusan, Korea.
3Department of Pathology, School of Medicine, Kyungpook National University, Taegu, Korea.
Abstract
This study was designed to determine the maximal safe drug concentration of intravitreal ciprofloxacin in phakic rabbit eyes. Twenty-two eyes of New Zealand pigmented rabbits received midvitreal ciprofloxacin of 100, 200, 400, 600 or 800 microgram in BSS Plus, or BSS Plus only. Retinal toxicity was dose-dependent as determined with electroretinography, light microscopy, and transmission electron microscopy. At a dose of greater than 400 microgram, disorganization of the outer segments was a main pathological finding in transmission electron microscopy. We evaluated retinal function by measuring the electroretinograms for a graded series of flash intensities and by fitting electroretinogram b-wave amplitudes to the Naka-Rushton equation. At a dose of greater than 600 microgram, Rmax was significantly decreased and log K was significantly increased. N-value tended to decrease. A decrease of b-wave amplitudes caused by retinal toxicity could be detected very sensitively with lower luminance stimuli. Determination of retinal toxicity with lower luminance electroretinography revealed a significant decrease of b-wave amplitudes at a dose of greater than 400 microgram. We concluded that a safe dose of intravitreal ciprofloxacin in phakic rabbit eyes was 200 microgram in phakic eyes.
Key Words: intravitreal ciprofloxacin;electroretinogram;Naka-Rushton equation parameters;electron microscory;retinal toxicity
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