Korean J Ophthalmol > Volume 16(1); 2002 > Article
Korean Journal of Ophthalmology 2002;16(1):1-7.
DOI: https://doi.org/10.3341/kjo.2002.16.1.1    Published online June 30, 2002.
Neuroprotective effect of memantine in a rabbit model of optic nerve ischemia.
Tae Woo Kim, Dong Myung Kim, Ki Ho Park, Hyunjoong Kim
Department of Ophthalmology, Seoul National University College of Medicine, Korea.
Abstract
The purpose of this study was to evaluate the neuroprotective effect of memantine, a N-methyl-D-aspartate antagonist, in an experimental optic nerve ischemia. Endothelin-1 (ET-1) in a dosage of 0.1 microg/day was delivered to the perineural region of the anterior optic nerve by osmotically driven minipumps for 8 weeks in 10 rabbits. In 5 rabbits, 1 mg/kg memantine was administered concurrently by intramuscular injection once a daily. Morphologic optic nerve head changes were monitored with a confocal scanning laser ophthalmoscope. Multivariate statistical analysis showed a significant change in topometric parameters (cup area, cup depth and rim volume), indicating an increase in optic nerve head cupping and a decrease of neural rim volume in the ET-1 administered eyes (P < 0.0001). In rabbits where memantine was given concurrently with ET-1, no significant change in topometric parameters was observed after ET-1 administration (P = 0.78). The current results suggest that memantine has a neuroprotective effect in optic nerve ischemia. Memantine may potentially be useful in the management of various ischemic disorders of the optic nerve, including glaucoma.
Key Words: endothelin-1;memantine;optic nerve ischemia
TOOLS
METRICS Graph View
  • 13 Crossref
  • 32 Scopus
  • 96 View
  • 1 Download
Related articles


ABOUT
BROWSE ARTICLES
EDITORIAL POLICY
FOR CONTRIBUTORS
Editorial Office
SKY 1004 Building #701
50-1 Jungnim-ro, Jung-gu, Seoul 04508, Korea
Tel: +82-2-583-6520    Fax: +82-2-583-6521    E-mail: kos@ophthalmology.org                

Copyright © 2021 by Korean Ophthalmological Society. All rights reserved.

Developed in M2PI

Close layer
prev next