Korean J Ophthalmol > Volume 17(1); 2003 > Article
Korean Journal of Ophthalmology 2003;17(1):35-43.
DOI: https://doi.org/10.3341/kjo.2003.17.1.35    Published online June 30, 2003.
Clinical Result of Prolonged Primary Chemotherapy in Retinoblastoma Patients.
Jeong Hun Kim, Young Suk Yu, Sang In Khwarg, Hyoung Soo Choi, Hee Young Shin, Hyo Seop Ahn
1Department of Ophthalmology, Seoul National University College of Medicine & Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
2Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
This study evaluated the effects of prolonged primary chemotherapy in retinoblastoma. The data for 27 eyes in 22 children who were treated for retinoblastoma with up to 13 cycles of primary chemotherapy was reviewed. The chemotherapy consisted of etoposide, vincristine, and either carboplatin or ifosfamide. In bilateral retinoblastoma, 1 eye was in each Ia, Ib, and Va, according to the Reese-Ellsworth classification, 2 in each IIa, IIIa, and IIIb, 4 in IIb, and 5 in IVa. Enucleation was performed in 1 in IIa and 1 in Va. In unilateral, 1 was in each IIa, IIIa, IVa, IVb, and Vb, and 4 in Va. Enucleation was performed in 8 with the exception of 1 in IIa. Complete regression was observed in 17 eyes (12 patients). There was no toxicity severe enough to delay treatment. Prolonged primary chemotherapy can be considered as an alternative treatment for retinoblastoma in III or less.
Key Words: cryotherapy;laser photocoagulation;prolonged primary chemotherapy;retinoblastoma

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