Korean J Ophthalmol > Volume 17(2); 2003 > Article
Korean Journal of Ophthalmology 2003;17(2):83-90.
DOI: https://doi.org/10.3341/kjo.2003.17.2.83    Published online December 30, 2003.
Effects of viscoelastic material on the corneal endothelial cells in trabeculectomy with adjunctive mitomycin-C.
D B Shin, S B Lee, C S Kim
Department of Ophthalmology, College of Medicine, Chungnam National University, Daejon, Korea.
We evaluated the change of corneal endothelium after trabeculectomy with mitomycin-C soaking (0.2 mg/ml, 2.4 +/- 1.2 minutes) and the effect of viscoelastic material in reducing this change. In randomly selected cases, 0.05 ml of sodium hyaluronate (Healon) was injected into anterior chamber (Healon group, n = 20), and same amount of balanced salt solution was injected in the other eyes (Control, n = 18) at the beginning of surgery. There were no differences in clinical variables and specular microscopy result between 2 groups before surgery. After surgery, the change of endothelial cells were significantly reduced in Healon group (cell density; -2.5 +/- 1.6%, variability of cell area; 5.8 +/- 2.5%, and percentage of hexagonal cell; -2.2 +/- 0.7%) compared to control group (-7.7 +/- 6.0%, 8.9 +/- 4.4%, and -4.8 +/- 3.5% respectively, p < 0.01). In trabeculectomy with mitomycin-C, the damage to the corneal endothelium was reduced significantly by injecting the viscoelastic material without significant complication.

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